Background：Interferon-induced antiviral RNA-binding protein that specifically binds single-stranded RNA bearing a 5'-triphosphate group(PPP-RNA), thereby acting as a sensor of viral single-stranded RNAs and inhibiting expression of viral messenger RNAs. Single-stranded PPP-RNAs, which lack 2'-O-methylation of the 5' cap and bear a 5'-triphosphate group instead, are specific from viruses, providing a molecular signature to distinguish between self and non-self mRNAs by the host during viral infection. Directly binds PPP-RNA in a non-sequence-specific manner. Viruses evolved several ways to evade this restriction system such as encoding their own 2'-O-methylase for their mRNAs or by stealing host cap containing the 2'-O-methylation(cap snatching mechanism). Exhibits antiviral activity against several viruses including human papilloma and hepatitis C viruses.
仕様
サイズ：100ug
Host：Rabbit
Specificity：Human
Clonality：polyclonal
Application：ELISA, IHC, WB
Isotype：IgG
Form：liquid
Purification：Immunogen affinity purified
Purity：≥95% as determined by SDS-PAGE
Immunogen：interferon-induced protein with tetratricopeptide repeats 1
