Background：Catalyzes the hydrolysis of GTP bound to the 40S ribosomal initiation complex(40S.mRNA.Met-tRNA[F].eIF-2.GTP) with the subsequent joining of a 60S ribosomal subunit resulting in the release of eIF-2 and the guanine nucleotide. The subsequent joining of a 60S ribosomal subunit results in the formation of a functional 80S initiation complex(80S.mRNA.Met-tRNA[F]).
