Background：May indirectly participate in activation of the NF-kappa-B and MAPK pathways. Acts as a mediator of BMP4-mediated modulation of canonical Wnt signaling activity in neural stem cells(By similarity). Required for DNA damage-induced ATM phosphorylation, p53 activation and cell cycle arrest. Involved in myelopoiesis. Transcription factor. Binds to the oxygen responsive element of COX4I2 and represses its transcription under hypoxia conditions(4% oxygen), as well as normoxia conditions(20% oxygen)(PubMed:23303788). May repress COX4I2 transactivation induced by CHCHD2 and RBPJ(PubMed:23303788).
