Background：Calcium-dependent phospholipid-binding protein that plays a role in calcium-mediated intracellular processes(PubMed:14674885). Involved in the TNF-alpha receptor signaling pathway in a calcium-dependent manner(PubMed:14674885). Exhibits calcium-dependent phospholipid binding properties(PubMed:9430674, PubMed:19539605). Plays a role in neuronal progenitor cell differentiation; induces neurite outgrowth via a AKT-dependent signaling cascade and calcium-independent manner(PubMed:23263657, PubMed:25450385). May recruit target proteins to the cell membrane in a calcium-dependent manner(PubMed:12522145). May function in membrane trafficking(PubMed:9430674). Involved in TNF-alpha-induced NF-kappa-B transcriptional repression by inducing endoprotease processing of the transcription factor NF-kappa-B p65/RELA subunit(PubMed:18212740). Also induces endoprotease processing of NF-kappa-B p50/NFKB1, p52/NFKB2, RELB and REL(PubMed:18212740).
