Background：Phosphatidylinositol 3,4,5-trisphosphate-dependent GTPase-activating protein that modulates actin cytoskeleton remodeling by regulating ARF and RHO family members. Is activated by phosphatidylinositol 3,4,5-trisphosphate(PtdIns(3,4,5)P3) binding. Can be activated by phosphatidylinositol 3,4-bisphosphate(PtdIns(3,4,5)P2) binding, albeit with lower efficiency. Acts on ARF6, RAC1, RHOA and CDC42. Plays a role in the internalization of anthrax toxin.
仕様
サイズ：100ug
Host：Rabbit
Specificity：Human
Clonality：polyclonal
Application：ELISA, IHC, WB
Isotype：IgG
Form：liquid
Purification：Immunogen affinity purified
Purity：≥95% as determined by SDS-PAGE
Immunogen：ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 3
