86-5850-55　anti- ALKBH3 antibody 100ug　FNab00312

特徴

• Background：Dioxygenase that mediates demethylation of DNA and RNA containing 1-methyladenosine(m1A)(PubMed:12486230, PubMed:12594517, PubMed:16174769, PubMed:26863196, PubMed:26863410). Repairs alkylated DNA containing 1-methyladenosine(m1A) and 3-methylcytosine(m3C) by oxidative demethylation(PubMed:12486230, PubMed:12594517, PubMed:16174769). Has a strong preference for single-stranded DNA(PubMed:12486230, PubMed:12594517, PubMed:16174769). Able to process alkylated m3C within double-stranded regions via its interaction with ASCC3, which promotes DNA unwinding to generate single-stranded substrate needed for ALKBH3(PubMed:22055184). Also acts on RNA(PubMed:12594517, PubMed:16174769, PubMed:26863196, PubMed:26863410, PubMed:16858410). Demethylates N(1)-methyladenosine(m1A) RNA, an epigenetic internal modification of messenger RNAs(mRNAs) highly enriched within 5'-untranslated regions(UTRs) and in the vicinity of start codons(PubMed:26863196, PubMed:26863410). Requires molecular oxygen, alpha-ketoglutarate and iron(PubMed:22055184, PubMed:16858410).

仕様

• サイズ：100ug
• Host：Rabbit
• Specificity：Human, Mouse
• Clonality：polyclonal
• Application：ELISA, WB, IHC
• Isotype：IgG
• Form：liquid
• Purification：Immunogen affinity purified
• Purity：≥95% as determined by SDS-PAGE
• Immunogen：alkB, alkylation repair homolog 3(E. coli)
• Manual Links：https://static.fn-test.com/product/manuals/antibody/FNab00312.pdf

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