Background：ITGA6, also named as CD49f and VLA-6, belongs to the integrin alpha chain family. It is a receptor for laminin on platelets. ITGA6 is a receptor for laminin in epithelial cells and it plays a critical structural role in the hemidesmosome. Defects in ITGA6 are a cause of epidermolysis bullosa letalis with pyloric atresia(EB-PA) which also known as junctional epidermolysis bullosa with pyloric atresia(PA-JEB) or aplasia cutis congenita with gastrointestinal atresia.
