86-4359-73 SPPL3 Antibody 100ug CSB-PA848402LA01HU
[WUHAN HUAMEI BIOTECH Co.,Ltd(CUSABIO)]特徴
- Background:Intramembrane-cleaving aspartic protease (I-CLiP) that cleaves type II membrane protein substrates in or close to their luminal transmembrane domain boundaries (PubMed:16873890, PubMed:25354954, PubMed:25827571). Acts like a sheddase by mediating the proteolytic release and secretion of active site-containing ectodomains of glycan-modifiying glycosidase and glycosyltransferase enzymes such as MGAT5, B4GAT1 and B4GALT1 (PubMed:25354954, PubMed:25827571). Catalyzes the intramembrane cleavage of the envelope glycoprotein gp130 and/or the leader peptide gp18LP of the simian foamy virus independent of prior ectodomain shedding by furin or furin-like proprotein convertase (PC)-mediated cleavage proteolysis (PubMed:23132852). May also have the ability to serve as a shedding protease for subsequent intramembrane proteolysis by SPPL2A and SPPL2B of the envelope glycoprotein gp130 (PubMed:23132852). Plays a role in the regulation of cellular glycosylation processes (PubMed:25354954). Required to link T-cell antigen receptor (TCR) and calcineurin-NFAT signaling cascades in lymphocytes by promoting the association of STIM1 and ORAI1 during store-operated calcium entry (SOCE) in a protease-independent manner (PubMed:25384971).
仕様
- Aliases:Signal peptide peptidase-like 3 (SPP-like 3) (EC 3.4.23.-) (Intramembrane protease 2) (IMP-2) (Presenilin homologous protein 1) (PSH1) (Presenilin-like protein 4), SPPL3, IMP2 PSL4
- Product Type:Polyclonal Antibody
- Immunogen Species:Human
- uniprot ID:Q8TCT6
- Immunogen:Recombinant Human Signal peptide peptidase-like 3 protein (213-263AA)
- Host Species:Rabbit
- Species Reactivity:Human
- Tested Applications:ELISA, WB, IF
- Clonality:Polyclonal
- Isotype:IgG
- Conjugate:Non-conjugated
- Buffer:Preservative: 0.03% Proclin 300<br />Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
- Form:Liquid
- Purification Method:>95%, Protein G purified
- Target Names:SPPL3
- Research Area:Cell Biology
- サイズ:100ug
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| 商品イメージ | アズワン品番 商品名 |
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86-4359-73
SPPL3 Antibody 100ug
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86-4359-74
SPPL3 Antibody 50ug
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