86-4359-73 SPPL3 Antibody 100ug CSB-PA848402LA01HU

[WUHAN HUAMEI BIOTECH Co.,Ltd(CUSABIO)]

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特徴

  • Background:Intramembrane-cleaving aspartic protease (I-CLiP) that cleaves type II membrane protein substrates in or close to their luminal transmembrane domain boundaries (PubMed:16873890, PubMed:25354954, PubMed:25827571). Acts like a sheddase by mediating the proteolytic release and secretion of active site-containing ectodomains of glycan-modifiying glycosidase and glycosyltransferase enzymes such as MGAT5, B4GAT1 and B4GALT1 (PubMed:25354954, PubMed:25827571). Catalyzes the intramembrane cleavage of the envelope glycoprotein gp130 and/or the leader peptide gp18LP of the simian foamy virus independent of prior ectodomain shedding by furin or furin-like proprotein convertase (PC)-mediated cleavage proteolysis (PubMed:23132852). May also have the ability to serve as a shedding protease for subsequent intramembrane proteolysis by SPPL2A and SPPL2B of the envelope glycoprotein gp130 (PubMed:23132852). Plays a role in the regulation of cellular glycosylation processes (PubMed:25354954). Required to link T-cell antigen receptor (TCR) and calcineurin-NFAT signaling cascades in lymphocytes by promoting the association of STIM1 and ORAI1 during store-operated calcium entry (SOCE) in a protease-independent manner (PubMed:25384971).

仕様

  • Aliases:Signal peptide peptidase-like 3 (SPP-like 3) (EC 3.4.23.-) (Intramembrane protease 2) (IMP-2) (Presenilin homologous protein 1) (PSH1) (Presenilin-like protein 4), SPPL3, IMP2 PSL4
  • Product Type:Polyclonal Antibody
  • Immunogen Species:Human
  • uniprot ID:Q8TCT6
  • Immunogen:Recombinant Human Signal peptide peptidase-like 3 protein (213-263AA)
  • Host Species:Rabbit
  • Species Reactivity:Human
  • Tested Applications:ELISA, WB, IF
  • Clonality:Polyclonal
  • Isotype:IgG
  • Conjugate:Non-conjugated
  • Buffer:Preservative: 0.03% Proclin 300<br />Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
  • Form:Liquid
  • Purification Method:>95%, Protein G purified
  • Target Names:SPPL3
  • Research Area:Cell Biology
  • サイズ:100ug
  • この商品は法規制を確認しておりません。(法規制によって販売できない場合もございます)
  • 【試薬に関するお問合せ】
  • アズワン株式会社 試薬・プロセス材料グループ
  • TEL:06-6447-8641
  • FAX:06-6447-8642
  • E-mail:[email protected]
アズワン品番
86-4359-73
型番
CSB-PA848402LA01HU
入り数
1個
標準価格
46,000円(税抜)
WEB価格
アズワン在庫 [?]
数量

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商品イメージ アズワン品番 商品名
86-4359-73
SPPL3 Antibody 100ug
86-4359-74
SPPL3 Antibody 50ug

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