86-4359-71 SPPL2A Antibody 100ug CSB-PA855050LA01HU
[WUHAN HUAMEI BIOTECH Co.,Ltd(CUSABIO)]特徴
- Background:Intramembrane-cleaving aspartic protease (I-CLiP) that cleaves type II membrane signal peptides in the hydrophobic plane of the membrane. Functions in FASLG, ITM2B and TNF processing (PubMed:16829952, PubMed:16829951, PubMed:17557115, PubMed:17965014). Catalyzes the intramembrane cleavage of the anchored fragment of shed TNF-alpha (TNF), which promotes the release of the intracellular domain (ICD) for signaling to the nucleus (PubMed:16829952). Also responsible for the intramembrane cleavage of Fas antigen ligand FASLG, which promotes the release of the intracellular FasL domain (FasL ICD) (PubMed:17557115). May play a role in the regulation of innate and adaptive immunity (PubMed:16829952). Catalyzes the intramembrane cleavage of the simian foamy virus envelope glycoprotein gp130 independently of prior ectodomain shedding by furin or furin-like proprotein convertase (PC)-mediated cleavage proteolysis (PubMed:23132852).
仕様
- Aliases:Signal peptide peptidase-like 2A (SPP-like 2A) (SPPL2a) (EC 3.4.23.-) (Intramembrane protease 3) (IMP-3) (Presenilin-like protein 2), SPPL2A, IMP3 PSL2
- Product Type:Polyclonal Antibody
- Immunogen Species:Human
- uniprot ID:Q8TCT8
- Immunogen:Recombinant Human Signal peptide peptidase-like 2A protein (26-172AA)
- Host Species:Rabbit
- Species Reactivity:Human
- Tested Applications:ELISA, WB, IHC, IF
- Clonality:Polyclonal
- Isotype:IgG
- Conjugate:Non-conjugated
- Buffer:Preservative: 0.03% Proclin 300<br />Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
- Form:Liquid
- Purification Method:>95%, Protein G purified
- Target Names:SPPL2A
- Research Area:Cell Biology
- サイズ:100ug
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86-4359-72
SPPL2A Antibody 50ug
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86-4359-71
SPPL2A Antibody 100ug
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