86-4359-22 SMARCC2 Antibody, FITC conjugated 50ul CSB-PA851527LC11HU
[WUHAN HUAMEI BIOTECH Co.,Ltd(CUSABIO)]
特徴
- Background：Involved in transcriptional activation and repression of select genes by chromatin remodeling （alteration of DNA-nucleosome topology）. Can stimulate the ATPase activity of the catalytic subunit of these complexes. May be required for CoREST dependent repression of neuronal specific gene promoters in non-neuronal cells. Belongs to the neural progenitors-specific chromatin remodeling complex （npBAF complex） and the neuron-specific chromatin remodeling complex （nBAF complex）. During neural development a switch from a stem/progenitor to a post-mitotic chromatin remodeling mechanism occurs as neurons exit the cell cycle and become committed to their adult state. The transition from proliferating neural stem/progenitor cells to post-mitotic neurons requires a switch in subunit composition of the npBAF and nBAF complexes. As neural progenitors exit mitosis and differentiate into neurons, npBAF complexes which contain ACTL6A/BAF53A and PHF10/BAF45A, are exchanged for homologous alternative ACTL6B/BAF53B and DPF1/BAF45B or DPF3/BAF45C subunits in neuron-specific complexes （nBAF）. The npBAF complex is essential for the self-renewal/proliferative capacity of the multipotent neural stem cells. The nBAF complex along with CREST plays a role regulating the activity of genes essential for dendrite growth （By similarity）.
仕様
- Aliases：SWI/SNF complex subunit SMARCC2 （BRG1-associated factor 170） （BAF170） （SWI/SNF complex 170 kDa subunit） （SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily C member 2）, SMARCC2, BAF170
- Product Type：Polyclonal
- Immunogen Species：Human
- uniprot ID：Q8TAQ2
- Immunogen：Recombinant Human SWI/SNF complex subunit SMARCC2 protein （300-647aa）
- Host Species：Rabbit
- Species Reactivity：Human
- Tested Applications：ELISA
- Clonality：Polyclonal
- Isotype：IgG
- Conjugate：FITC
- Buffer：Preservative： 0.03％ Proclin 300＜br /＞Constituents： 50％ Glycerol, 0.01M PBS, pH 7.4
- Form：Liquid
- Purification Method：＞95％, Protein G purified
- Target Names：SMARCC2
- Research Area：Epigenetics and Nuclear Signaling
- サイズ：50ul
- この商品は法規制を確認しておりません。（法規制によって販売できない場合もございます）
- 【試薬に関するお問合せ】
- アズワン株式会社 試薬・プロセス材料グループ
- TEL：06-6447-8641
- FAX：06-6447-8642
- E-mail：[email protected]
商品のバリエーション （サイズ違い・スペック違い・オプション品など）
| 商品イメージ | アズワン品番 商品名 |
|---|---|
|
86-4359-22
SMARCC2 Antibody, FITC conjugated 50ul
|
|
|
86-4359-20
SMARCC2 Antibody, FITC conjugated 100ul
|
|
|
86-4359-21
SMARCC2 Antibody, FITC conjugated 50ul
|
よくあるご質問（FAQ）
掲載カタログ情報
| 掲載カタログ名 | 掲載ページ |
|---|