86-4358-22 SGO1 Antibody 100ug CSB-PA688764LA01HU
[WUHAN HUAMEI BIOTECH Co.,Ltd(CUSABIO)]
特徴
- Background：Plays a central role in chromosome cohesion during mitosis by preventing premature dissociation of cohesin complex from centromeres after prophase, when most of cohesin complex dissociates from chromosomes arms. May act by preventing phosphorylation of the STAG2 subunit of cohesin complex at the centromere, ensuring cohesin persistence at centromere until cohesin cleavage by ESPL1/separase at anaphase. Essential for proper chromosome segregation during mitosis and this function requires interaction with PPP2R1A. Its phosphorylated form is necessary for chromosome congression and for the proper attachment of spindle microtubule to the kinetochore. Necessary for kinetochore localization of PLK1 and CENPF. May play a role in the tension sensing mechanism of the spindle-assembly checkpoint by regulating PLK1 kinetochore affinity. Isoform 3 plays a role in maintaining centriole cohesion involved in controlling spindle pole integrity.
仕様
- Aliases：Shugoshin 1 （Serologically defined breast cancer antigen NY-BR-85） （Shugoshin-like 1）, SGO1, SGOL1
- Product Type：Polyclonal Antibody
- Immunogen Species：Human
- uniprot ID：Q5FBB7
- Immunogen：Recombinant Human Shugoshin 1 protein （260-439AA）
- Host Species：Rabbit
- Species Reactivity：Human, Mouse
- Tested Applications：ELISA, WB, IF
- Clonality：Polyclonal
- Isotype：IgG
- Conjugate：Non-conjugated
- Buffer：Preservative： 0.03％ Proclin 300＜br /＞Constituents： 50％ Glycerol, 0.01M PBS, pH 7.4
- Form：Liquid
- Purification Method：＞95％, Protein G purified
- Target Names：SGO1
- Research Area：Epigenetics and Nuclear Signaling
- サイズ：100ug
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商品のバリエーション （サイズ違い・スペック違い・オプション品など）
| 商品イメージ | アズワン品番 商品名 |
|---|---|
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86-4358-22
SGO1 Antibody 100ug
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86-4358-23
SGO1 Antibody 50ug
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