86-4357-24 RNF126 Antibody 100ug CSB-PA019828LA01HU
[WUHAN HUAMEI BIOTECH Co.,Ltd(CUSABIO)]
特徴
- Background：E3 ubiquitin-protein ligase that regulates several biological processes through ubiquitination of various target proteins. Depending on the associated E2 ligase, mediates 'Lys-48'- and 'Lys-63'-linked polyubiquitination of substrates. Through their polyubiquitination, may play a role in the endosomal sorting and degradation of several membrane receptors including EGFR, FLT3, MET and CXCR4. May also be part of a BAG6-dependent quality control process ensuring that proteins of the secretory pathway that are mislocalized to the cytosol are degraded by the proteasome. May provide the ubiquitin ligase activity associated with the BAG6 complex and be responsible for ubiquitination of the mislocalized proteins and their targeting to the proteasome （PubMed：24981174）. May also play a role in the endosomal recycling of IGF2R, the cation-independent mannose-6-phosphate receptor （PubMed：24275455）. By ubiquitinating CDKN1A/p21 and targeting it for degradation, may also promote cell proliferation （PubMed：23026136）. May monoubiquitinate AICDA （PubMed：23277564）.
仕様
- Aliases：E3 ubiquitin-protein ligase RNF126 （EC 2.3.2.27） （RING finger protein 126）, RNF126
- Product Type：Polyclonal Antibody
- Immunogen Species：Human
- uniprot ID：Q9BV68
- Immunogen：Recombinant Human E3 ubiquitin-protein ligase RNF126 protein （39-225AA）
- Host Species：Rabbit
- Species Reactivity：Human, Mouse
- Tested Applications：ELISA, WB, IHC, IF
- Clonality：Polyclonal
- Isotype：IgG
- Conjugate：Non-conjugated
- Buffer：Preservative： 0.03％ Proclin 300＜br /＞Constituents： 50％ Glycerol, 0.01M PBS, pH 7.4
- Form：Liquid
- Purification Method：＞95％, Protein G purified
- Target Names：RNF126
- Research Area：Cell Biology
- サイズ：100ug
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商品のバリエーション （サイズ違い・スペック違い・オプション品など）
| 商品イメージ | アズワン品番 商品名 |
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86-4357-24
RNF126 Antibody 100ug
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86-4357-25
RNF126 Antibody 50ug
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