Background：＜p＞Promotes microtubule assembly and stability, and might be involved in the establishment and maintenance of neuronal polarity. The C-terminus binds axonal microtubules while the N-terminus binds neural plasma membrane components, suggesting that tau functions as a linker protein between both. Axonal polarity is predetermined by tau localization （in the neuronal cell） in the domain of the cell body defined by the centrosome. The short isoforms allow plasticity of the cytoskeleton whereas the longer isoforms may preferentially play a role in its stabilization. ＜br /＞＜br /＞Goedert M., Proc. Natl. Acad. Sci. U.S.A. 85：4051-4055（1988）.＜br /＞Goedert M., EMBO J. 8：393-399（1989）.＜br /＞Lee G., Neuron 2：1615-1624（1989）.＜/p＞
仕様
Aliases：MAPT; MTBT1; PHF-tau;
Product Type：Polyclonal Antibody
Immunogen Species：Human
uniprot ID：P10636
Immunogen：Peptide sequence around phosphorylation site of threonine 217（L-P-T（p）-P-P） derived from Human Tau.
Host Species：Rabbit
Species Reactivity：Human, Mouse, Rat
Tested Applications：ELISA, WB
Clonality：Polyclonal
Isotype：IgG
Conjugate：Non-conjugated
Buffer：Rabbit IgG in phosphate buffered saline （without Mg2+ and Ca2+）, pH 7.4, 150mM NaCl, 0.02％ sodium azide and 50％ glycerol.
Form：liquid
Purification Method：Antibodies were produced by immunizing rabbits with synthetic phosphopeptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific phosphopeptide. Non-phospho specific antibodies were removed by chromatogramphy using non-phosphopeptide.
