86-4354-45 NDFIP1 Antibody 50ug CSB-PA887119LA01HU
[WUHAN HUAMEI BIOTECH Co.,Ltd(CUSABIO)]
特徴
- Background：Activates HECT domain-containing E3 ubiquitin-protein ligases, including NEDD4 and ITCH, and consequently modulates the stability of their targets. As a result, controls many cellular processes. Prevents chronic T-helper cells-mediated inflammation by activating ITCH and thus controlling JUNB degradation （By similarity）. In cortical neurons, mediates the ubiquitination of SLC11A2/DMT1 by NEDD4L, leading to down-regulation of the divalent metal transporter and protection of the cells from cobalt and iron toxicity （PubMed：19706893）. Modulates EGFR signaling through multiple pathways. In particular, may regulate the ratio of AKT1-to-MAPK8 signaling in response to EGF, acting on AKT1 probably through PTEN destabilization and on MAPK8 through ITCH-dependent MAP2K4 inactivation. As a result, may control cell growth rate （PubMed：20534535）. Enhances the ubiquitination of BRAT1 mediated by E3 ubiquitin-protein ligases： NEDD4, NEDD4L and ITCH, and is required for the nuclear localization of ubiquitinated BRAT1 （PubMed：25631046）.
仕様
- Aliases：NEDD4 family-interacting protein 1 （Breast cancer-associated protein SGA-1M） （NEDD4 WW domain-binding protein 5） （Putative MAPK-activating protein PM13） （Putative NF-kappa-B-activating protein 164） （Putative NFKB and MAPK-activating protein）, NDFIP1, N4WBP5
- Product Type：Polyclonal Antibody
- Immunogen Species：Human
- uniprot ID：Q9BT67
- Immunogen：Recombinant Human NEDD4 family-interacting protein 1 protein （2-116AA）
- Host Species：Rabbit
- Species Reactivity：Human
- Tested Applications：ELISA, WB, IHC, IF
- Clonality：Polyclonal
- Isotype：IgG
- Conjugate：Non-conjugated
- Buffer：Preservative： 0.03％ Proclin 300＜br /＞Constituents： 50％ Glycerol, 0.01M PBS, PH 7.4
- Form：Liquid
- Purification Method：＞95％, Protein G purified
- Target Names：NDFIP1
- Research Area：Cell Biology
- サイズ：50ug
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86-4354-44
NDFIP1 Antibody 100ug
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86-4354-45
NDFIP1 Antibody 50ug
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