86-4352-78 LRP8 Antibody 100ug CSB-PA623900LA01HU
[WUHAN HUAMEI BIOTECH Co.,Ltd(CUSABIO)]
特徴
- Background：Cell surface receptor for Reelin （RELN） and apolipoprotein E （apoE）-containing ligands. LRP8 participates in transmitting the extracellular Reelin signal to intracellular signaling processes, by binding to DAB1 on its cytoplasmic tail. Reelin acts via both the VLDL receptor （VLDLR） and LRP8 to regulate DAB1 tyrosine phosphorylation and microtubule function in neurons. LRP8 has higher affinity for Reelin than VLDLR. LRP8 is thus a key component of the Reelin pathway which governs neuronal layering of the forebrain during embryonic brain development. Binds the endoplasmic reticulum resident receptor-associated protein （RAP）. Binds dimers of beta 2-glycoprotein I and may be involved in the suppression of platelet aggregation in the vasculature. Highly expressed in the initial segment of the epididymis, where it affects the functional expression of clusterin and phospholipid hydroperoxide glutathione peroxidase （PHGPx）, two proteins required for sperm maturation. May also function as an endocytic receptor.
仕様
- Aliases：Low-density lipoprotein receptor-related protein 8 （LRP-8） （Apolipoprotein E receptor 2）, LRP8, APOER2
- Product Type：Polyclonal Antibody
- Immunogen Species：Human
- uniprot ID：Q14114
- Immunogen：Recombinant Human Low-density lipoprotein receptor-related protein 8 protein （131-332AA）
- Host Species：Rabbit
- Species Reactivity：Human
- Tested Applications：ELISA, WB, IF
- Clonality：Polyclonal
- Isotype：IgG
- Conjugate：Non-conjugated
- Buffer：Preservative： 0.03％ Proclin 300＜br /＞Constituents： 50％ Glycerol, 0.01M PBS, PH 7.4
- Form：Liquid
- Purification Method：＞95％, Protein G purified
- Target Names：LRP8
- Research Area：Neuroscience
- サイズ：100ug
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86-4352-79
LRP8 Antibody 50ug
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86-4352-78
LRP8 Antibody 100ug
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