86-4349-76 GNA12 Antibody 100ug CSB-PA009584LA01HU

[WUHAN HUAMEI BIOTECH Co.,Ltd(CUSABIO)]

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特徴

  • Background:Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems (PubMed:22609986, PubMed:15525651, PubMed:15240885, PubMed:17565996, PubMed:12515866, PubMed:16787920, PubMed:16705036, PubMed:23762476, PubMed:27084452). Activates effector molecule RhoA by binding and activating RhoGEFs (ARHGEF12/LARG) (PubMed:15240885, PubMed:12515866, PubMed:16202387). GNA12-dependent Rho signaling subsequently regulates transcription factor AP-1 (activating protein-1) (By similarity). GNA12-dependent Rho signaling also regulates protein phosphatese 2A activation causing dephosphorylation of its target proteins (PubMed:15525651, PubMed:17565996). Promotes tumor cell invasion and metastasis by activating RhoA/ROCK signaling pathway and up-regulating proinflammatory cytokine production (PubMed:23762476, PubMed:16787920, PubMed:16705036, PubMed:27084452). Inhibits CDH1-mediated cell adhesion in process independent from Rho activation (PubMed:11976333, PubMed:16787920). Together with NAPA promotes CDH5 localization to plasma membrane (PubMed:15980433). May play a role in the control of cell migration through the TOR signaling cascade (PubMed:22609986).

仕様

  • Aliases:Guanine nucleotide-binding protein subunit alpha-12 (G alpha-12) (G-protein subunit alpha-12), GNA12
  • Product Type:Polyclonal Antibody
  • Immunogen Species:Human
  • uniprot ID:Q03113
  • Immunogen:Recombinant Human Guanine nucleotide-binding protein subunit alpha-12 protein (112-270AA)
  • Host Species:Rabbit
  • Species Reactivity:Human
  • Tested Applications:ELISA, WB, IHC, IF
  • Clonality:Polyclonal
  • Isotype:IgG
  • Conjugate:Non-conjugated
  • Buffer:Preservative: 0.03% Proclin 300<br />Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
  • Form:Liquid
  • Purification Method:>95%, Protein G purified
  • Target Names:GNA12
  • Research Area:Signal Transduction
  • サイズ:100ug
  • この商品は法規制を確認しておりません。(法規制によって販売できない場合もございます)
  • 【試薬に関するお問合せ】
  • アズワン株式会社 試薬・プロセス材料グループ
  • TEL:06-6447-8641
  • FAX:06-6447-8642
  • E-mail:[email protected]
アズワン品番
86-4349-76
型番
CSB-PA009584LA01HU
入り数
1個
標準価格
46,000円(税抜)
WEB価格
アズワン在庫 [?]
数量

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商品イメージ アズワン品番 商品名
86-4349-77
GNA12 Antibody 50ug
86-4349-76
GNA12 Antibody 100ug

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