86-4349-76 GNA12 Antibody 100ug CSB-PA009584LA01HU
[WUHAN HUAMEI BIOTECH Co.,Ltd(CUSABIO)]特徴
- Background:Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems (PubMed:22609986, PubMed:15525651, PubMed:15240885, PubMed:17565996, PubMed:12515866, PubMed:16787920, PubMed:16705036, PubMed:23762476, PubMed:27084452). Activates effector molecule RhoA by binding and activating RhoGEFs (ARHGEF12/LARG) (PubMed:15240885, PubMed:12515866, PubMed:16202387). GNA12-dependent Rho signaling subsequently regulates transcription factor AP-1 (activating protein-1) (By similarity). GNA12-dependent Rho signaling also regulates protein phosphatese 2A activation causing dephosphorylation of its target proteins (PubMed:15525651, PubMed:17565996). Promotes tumor cell invasion and metastasis by activating RhoA/ROCK signaling pathway and up-regulating proinflammatory cytokine production (PubMed:23762476, PubMed:16787920, PubMed:16705036, PubMed:27084452). Inhibits CDH1-mediated cell adhesion in process independent from Rho activation (PubMed:11976333, PubMed:16787920). Together with NAPA promotes CDH5 localization to plasma membrane (PubMed:15980433). May play a role in the control of cell migration through the TOR signaling cascade (PubMed:22609986).
仕様
- Aliases:Guanine nucleotide-binding protein subunit alpha-12 (G alpha-12) (G-protein subunit alpha-12), GNA12
- Product Type:Polyclonal Antibody
- Immunogen Species:Human
- uniprot ID:Q03113
- Immunogen:Recombinant Human Guanine nucleotide-binding protein subunit alpha-12 protein (112-270AA)
- Host Species:Rabbit
- Species Reactivity:Human
- Tested Applications:ELISA, WB, IHC, IF
- Clonality:Polyclonal
- Isotype:IgG
- Conjugate:Non-conjugated
- Buffer:Preservative: 0.03% Proclin 300<br />Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
- Form:Liquid
- Purification Method:>95%, Protein G purified
- Target Names:GNA12
- Research Area:Signal Transduction
- サイズ:100ug
- この商品は法規制を確認しておりません。(法規制によって販売できない場合もございます)
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商品のバリエーション (サイズ違い・スペック違い・オプション品など)
| 商品イメージ | アズワン品番 商品名 |
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86-4349-77
GNA12 Antibody 50ug
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86-4349-76
GNA12 Antibody 100ug
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