86-4345-06 BTRC Antibody 100ug CSB-PA897464LA01HU
[WUHAN HUAMEI BIOTECH Co.,Ltd(CUSABIO)]
特徴
- Background：Substrate recognition component of a SCF （SKP1-CUL1-F-box protein） E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Recognizes and binds to phosphorylated target proteins. SCF（BTRC） mediates the ubiquitination of CTNNB1 and participates in Wnt signaling. SCF（BTRC） mediates the ubiquitination of NFKBIA, NFKBIB and NFKBIE; the degradation frees the associated NFKB1 to translocate into the nucleus and to activate transcription. Ubiquitination of NFKBIA occurs at 'Lys-21' and 'Lys-22'. SCF（BTRC） mediates the ubiquitination of CEP68; this is required for centriole separation during mitosis （PubMed：25704143, PubMed：25503564）. SCF（BTRC） mediates the ubiquitination of phosphorylated NFKB1/nuclear factor NF-kappa-B p105 subunit, ATF4, CDC25A, DLG1, FBXO5, PER1, SMAD3, SMAD4, SNAI1 and probably NFKB2. Has an essential role in the control of the clock-dependent transcription via degradation of phosphorylated PER1 and PER2. May be involved in ubiquitination and subsequent proteasomal degradation through a DBB1-CUL4 E3 ubiquitin-protein ligase. Required for activation of NFKB-mediated transcription by IL1B, MAP3K14, MAP3K1, IKBKB and TNF. Required for proteolytic processing of GLI3.
仕様
- Aliases：F-box/WD repeat-containing protein 1A （E3RSIkappaB） （Epididymis tissue protein Li 2a） （F-box and WD repeats protein beta-TrCP） （pIkappaBalpha-E3 receptor subunit）, BTRC, BTRCP FBW1A FBXW1A
- Product Type：Polyclonal Antibody
- Immunogen Species：Human
- uniprot ID：Q9Y297
- Immunogen：Recombinant Human F-box/WD repeat-containing protein 1A protein （397-448AA）
- Host Species：Rabbit
- Species Reactivity：Human
- Tested Applications：ELISA, WB, IHC, IF
- Clonality：Polyclonal
- Isotype：IgG
- Conjugate：Non-conjugated
- Buffer：Preservative： 0.03％ Proclin 300＜br /＞Constituents： 50％ Glycerol, 0.01M PBS, PH 7.4
- Form：Liquid
- Purification Method：＞95％, Protein G purified
- Target Names：BTRC
- Research Area：Microbiology
- サイズ：100ug
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商品のバリエーション （サイズ違い・スペック違い・オプション品など）
| 商品イメージ | アズワン品番 商品名 |
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86-4345-06
BTRC Antibody 100ug
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86-4345-07
BTRC Antibody 50ug
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