Background：CD279, also known as programmed death-1 （PD-1）, is a 50-55 kD glycoprotein belonging to the CD28 family of the Ig superfamily. PD-1 is expressed on activated splenic T and B cells and thymocytes. It is induced on activated myeloid cells as well. PD-1 is involved in lymphocyte clonal selection and peripheral tolerance through binding its ligands, B7-H1 （PD-L1） and B7-DC （PD-L2）. It has been reported that PD-1 and PD-L1 interactions are critical to positive selection and play a role in shaping the T cell repertoire. PD-L1 negative costimulation is essential for prolonged survival of intratesticular islet allografts.
Buffer：0.2 um filtered in PBS, pH7.2. Azide Free （AF）/Low Endotoxin （LE）： Contains no stabilizers or preservatives. Endotoxin level is ＜ 2 EU/mg （ ＜ 0.002EU/ug） as Determined by LAL gel clotting assay.
