Background：CD120b is a 75 kD type I transmembrane protein, also known as Tumor Necrosis Factor Receptor Type II （TNFRII） or p75. It is expressed on a variety of cells at low levels; the expression is upregulated upon activation. This receptor binds both TNF-a and LT-a （also known as TNF-b）. In association with TRAF1 and TRAF2, the receptor crosslinking induced by TNF-a or LT-a trimers is critical for signal transduction, leading to apoptosis, NF-kB activation, increased expression of proinflammatory genes, tumor necrosis, and cell differentiation depending on cell type and differentiation state.
Buffer：0.2 um filtered in PBS, pH7.2. Azide Free （AF）/Low Endotoxin （LE）： Contains no stabilizers or preservatives. Endotoxin level is ＜ 2 EU/mg （ ＜ 0.002EU/ug） as Determined by LAL gel clotting assay.
