Background：CD120b is a 75 kD type I transmembrane protein, also known as Tumor Necrosis Factor Receptor Type II （TNFRII） or p75. It is expressed on a variety of cells at low levels; the expression is upregulated upon activation. This receptor binds both TNF-a and LT-a （also known as TNF-b）. In association with TRAF1 and TRAF2, the receptor crosslinking induced by TNF-a or LT-a trimers is critical for signal transduction, leading to apoptosis, NF-kB activation, increased expression of proinflammatory genes, tumor necrosis, and cell differentiation depending on cell type and differentiation state.
