Background：Macrophage mannose receptor （MMR） is a 162-175 kD type I membrane protein also known as CD206, MRC1, or mannose receptor （MR）. It is a pattern recognition receptor （PRR） that belongs to C-type lectin superfamily. MMR is expressed on macrophages, dendritic cells, and hepatic or lymphatic endothelial cells, but not on monocytes. MMR recognizes a range of microbial carbohydrates bearing mannose, fucose, or N-acetyl glucosamine. MMR mediates endocytosis and phagocytosis, induces activation of macrophages and antigen presentation, plays an important role in host defense, and provides a link between innate and adaptive immunity.
