Background：CD40 is a 48 kD type I transmembrane glycoprotein also known as Bp50. It is a member of the tumor necrosis factor receptor （TNFR） superfamily and is expressed on B cells, basal epithelial cells, macrophages, follicular dendritic cells, endothelial cells, and a subset of CD34+ hematopoietic progenitors. CD40 regulates B cell development/maturation, Ig isotype switching and, in combination with other signals such as IL-4, protects B cells from surface Ig-induced apoptosis and promotes proliferation. Interaction of CD40 with its ligand CD154 （gp39）, which is expressed on activated T cells, is important in costimulation and immune regulation.
Buffer：0.2 um filtered in PBS, pH7.2. Azide Free （AF）/Low Endotoxin （LE）： Contains no stabilizers or preservatives. Endotoxin level is ＜ 2 EU/mg （ ＜ 0.002EU/ug） as Determined by LAL gel clotting assay.
