Background：FOXP3 is a 50-55 kD transcription factor, also known as Forkhead box protein P3, Scurfin, JM2, or IPEX. It is proposed to be a master regulatory gene and more specific marker of T regulatory cells than most cell surface markers （such as CD4 and CD25）. Transduced expression of FOXP3 in CD4+/CD25- cells has been shown to induce GITR, CD103, and CTLA4 and impart a T regulatory cell phenotype. FOXP3 is mutated in X-linked autoimmunity-allergic dysregulation syndrome （XLAAD or IPEX） in humans and in "scurfy" mice. Overexpression of FOXP3 has been shown to lead to a hypoactive immune state suggesting that this transcriptional factor is a central regulator of T cell activity. In human, unlike in mouse, two isoforms of FOXP3 have been reported： one （FOXP3） corresponding to the canonical full-length sequence; the other （FOXP3 delta2） lacking exon 2.
仕様
Synonyms：Forkhead box protein P3,FOXP3,Scurfin,Forkhead box protein P3 41 kDa form,IPEX
