Background：CD19 is a 95 kD type I transmembrane glycoprotein also known as B4. It is a member of the immunoglobulin superfamily expressed on B-cells （from pro-B to blastoid B cells, absent on plasma cells） and follicular dendritic cells. CD19 is involved in B cell development, activation, and differentiation. CD19 forms a complex with CD21 （CR2） and CD81 （TAPA-1）, and functions as a BCR co-receptor.
