Background：CD16 is known as low affinity IgG receptor III （FcgammaRIII）. It is expressed as two distinct forms （CD16a and CD16b）. CD16a （FcgammaRIIIA） is a 50-65 kD polypeptide-anchored transmembrane protein. It is expressed on the surface of NK cells, activated monocytes, macrophages, and placental trophoblasts in humans. CD16b （FcgammaRIIIB） is a 48 kD glycosylphosphatidylinositol （GPI）-anchored protein. Its extracellular domain is over 95％ homologous to that of CD16a, and it is expressed specifically on neutrophils. CD16 binds aggregated IgG or IgG-antigen complex which functions in NK cell activation, phagocytosis, and antibody-dependent cell-mediated cytotoxicity （ADCC）.
仕様
Synonyms：Low affinity immunoglobulin gamma Fc region receptor III-A,FCGR3A,CD16a antigen,Fc-gamma RIII-alpha,Fc-gamma RIII,Fc-gamma RIIIa,FcRIII,FcRIIIa,FcR-10,IgG Fc receptor III-2,CD16a
