Background：CD49d is a 150 kD a integrin chain known as a4 integrin or VLA-4 a chain. It forms a heterodimer with either integrin b1 （a4b1, VLA-4） or b7 （a4b7）. CD49d is expressed broadly on T lymphocytes, B lymphocytes, monocytes, thymocytes, eosinophils, basophils, mast cells, NK cells, dendritic cells, and some non-hematopoietic cells, but not on normal red blood cells, platelets or neutrophils. VLA-4 binds to VCAM-1 （CD106） and fibronectin. a4b7 is the receptor for VCAM-1 and MAdCAM-1. CD49d participates in mononuclear cell trafficking to endothelial sites of inflammation and has roles in cell-cell interactions and cell adhesion to extracellular matrices. CD49d is involved in lymphocyte migration, T cell activation, and hematopoietic stem cell differentiation. CD49d is a marker to isolate pure populations of Treg cells due to its absence on Foxp3+ cells.
仕様
Synonyms：Integrin alpha-4,ITGA4,CD49 antigen-like family member D,Integrin alpha-IV,VLA-4 subunit alpha,CD49d
