Background：CD14 is a 53-55 kD glycosylphosphatidylinositol （GPI）-linked membrane glycoprotein also known as LPS receptor. CD14 is expressed on macrophages, dendritic cells, Kupffer cells, hepatocytes, and granulocytes. As a high-affinity receptor for LPS-LBP （LPS-binding protein） complex, CD14, in association with Toll-like Receptor 4 （TLR4） or 2 （TLR2）, is involved in the clearance of gram-negative pathogens.
