Background：This gene encodes a member of the receptor-interacting protein （RIP） family of serine/threonine protein kinases. The encoded protein contains a C-terminal caspase activation and recruitment domain （CARD）, and is a component of signaling complexes in both the innate and adaptive immune pathways. It is a potent activator of NF-kappaB and inducer of apoptosis in response to various stimuli.RIPK2 （Receptor Interacting Serine/Threonine Kinase 2） is a Protein Coding gene. Diseases associated with RIPK2 include Lymphoproliferative Syndrome, X-Linked, 2 and Human Granulocytic Anaplasmosis. Among its related pathways are IL-1 signaling pathway and Nucleotide-binding domain, leucine rich repeat containing receptor （NLR） signaling pathways. GO annotations related to this gene include protein homodimerization activity and protein kinase activity. An important paralog of this gene is RIPK4.
仕様
Synonyms：CARD 3,CARD carrying kinase,CARD containing ICE associated kinase,CARD containing IL 1 beta ICE kinase,CARD containing IL1 beta ICE kinase,CARD containing interleukin 1 beta converting enzyme （ICE） associated kinase,CARD containing interleukin 1 beta converting enzyme associated kinase,CARD-containing IL-1 beta ICE-kinase,CARD-containing interleukin-1 beta-converting enzyme-associated kinase,CARD3,CARDIAK,CCK,CLARP kinase,GIG 30,GIG30,Growth inhibiting gene 30,Receptor interacting protein （RIP） like interacting caspase like apoptosis regulatory protein （CLARP） kinase,Receptor interacting protein 2,Receptor interacting serine threonine kinase 2,Receptor interacting serine/threonine protein kinase 2,Receptor-interacting protein 2,Receptor-interacting serine/threonine-protein kinase 2,RICK,RIP 2,RIP like interacting CLARP kinase,RIP-2,RIP-like-interacting CLARP kinase,RIPK 2,Ripk2,RIPK2,TNFRSF,Tyrosine-protein kinase RIPK2,UNQ277/PRO314/PRO34092
Host：Rabbit
Reactivity：Human,Mouse,Rat
Applications：WB,ELISA
Concentration：1mg/mL
Immunogen：Synthesized phospho derived from human RIPK2 （Phospho-Ser176）
Purification Method：Affinity purification
Clonality：Polyclonal
Conjugation：Unconjugated
Buffer：PBS with 0.02％ sodium azide,0.5％ BSA and 50％ glycerol pH 7.4.
Dilution：WB 1：500-2000, ELISA 1：10000-20000
Gene_ID（human）：8767
Swissprot：O43353
Isotype：IgG
Research Areas：Cancer, Cell Biology, Metabolism, Immunology, Signal transduction
