Background：MERTK is a member of the MER/AXL/TYRO3 receptor kinase family and encodes a transmembrane protein with two fibronectin type-III domains, two Ig-like C2-type （immunoglobulin-like） domains, and one tyrosine kinase domain. Mutations in this gene have been associated with disruption of the retinal pigment epithelium （RPE） phagocytosis pathway and onset of autosomal recessive retinitis pigmentosa （RP）.MERTK （MER Proto-Oncogene, Tyrosine Kinase） is a Protein Coding gene. Diseases associated with MERTK include Retinitis Pigmentosa 38 and Mertk-Related Retinitis Pigmentosa. Among its related pathways are GPCR Pathway and Nanog in Mammalian ESC Pluripotency. GO annotations related to this gene include transferase activity, transferring phosphorus-containing groups and protein tyrosine kinase activity. An important paralog of this gene is AXL.TYRO3 （TYRO3 Protein Tyrosine Kinase） is a Protein Coding gene. Diseases associated with TYRO3 include External Ear Carcinoma and Lymphocytic Choriomeningitis. Among its related pathways are GPCR Pathway and Nanog in Mammalian ESC Pluripotency. GO annotations related to this gene include transferase activity, transferring phosphorus-containing groups and protein tyrosine kinase activity. An important paralog of this gene is AXL.
仕様
Synonyms：AI323366,Brt,Bruton agammaglobulinemia tyrosine kinase,BYK,c-mer,c-mer proto-oncogene tyrosine kinase,Dtk,Etk 2,Eyk,FLJ16467,Mer,MER receptor tyrosine kinase,MERTK,MGC133349,Nyk,OTTMUSP00000017810,rdy,Receptor tyrosine kinase,Receptor tyrosine kinase MerTK,Receptor tyrosine tinase gene probably the gene for Rdy,Retinal dystrophy,RP23-30M20.1,RP23-356L21.1,RP38,RSE,Sky,STK kinase,Tif,TYRO3,TYRO3 protein tyrosine kinase 3,TYRO3 protein tyrosine kinase,Tyrosine protein kinase byk,Tyrosine protein kinase DTK,Tyrosine protein kinase RSE,Tyrosine protein kinase SKY
Host：Rabbit
Reactivity：Human,Mouse,Rat
Applications：WB,ELISA
Concentration：1mg/mL
Immunogen：Synthetic peptide from human protein
Purification Method：Affinity purification
Clonality：Polyclonal
Conjugation：Unconjugated
Buffer：PBS with 0.02％ sodium azide and 50％ glycerol pH 7.4.
Dilution：WB 1：500-10000, ELISA 1：10000
Gene_ID（human）：10461/7301
Swissprot：Q12866,Q06418
Isotype：IgG
Research Areas：Cancer, Neuroscience, Signal transduction
