Background：The JNK-interacting protein （JIP） group of scaffold proteins selectively mediates JNK signaling by aggregating specific components of the MAPK cascade to form a functional JNK signaling module and is required for JNK activation in response to excitotoxic stress. Cytoplasmic JIP1 causes inhibition of JNK-regulated activity by retaining JNK in the cytoplasm and inhibiting JNK phosphorylation of c-Jun. It may also participate in ApoER2-specific reelin signaling and directly, or indirectly, regulates GLUT2 gene expression and beta-cell function. It appears to have a role in cell signaling in mature and developing nerve terminals and may function as a regulator of vesicle transport, through interactions with the JNK-signaling components and motor proteins. It functions as an anti-apoptotic protein whose level seems to influence the beta-cell death or survival response.
仕様
Synonyms：C jun amino terminal kinase interacting protein 1,C-jun-amino-terminal kinase-interacting protein 1,IB 1,IB-1,IB1,Islet brain 1,Islet-brain 1,JIP 1,JIP-1,JIP1,JNK interacting protein 1,JNK MAP kinase scaffold protein 1,JNK-interacting protein 1,MAPK8IP 1,MAPK8IP1,MAPK8IP1 mitogen-activated protein kinase 8 interacting protein 1,Mitogen activated protein kinase 8 interacting protein 1,Mitogen-activated protein kinase 8-interacting protein 1,PRKM8,PRKM8 interacting protein,PRKM8IP
Host：Rabbit
Reactivity：Human,Mouse,Rat
Applications：WB,IHC-p,IF,ELISA
Concentration：1mg/mL
Immunogen：Synthesized peptide derived from human JIP-1 around the phosphorylation site of T103.
Purification Method：Affinity purification
Clonality：Polyclonal
Conjugation：Unconjugated
Buffer：PBS with 0.02％ sodium azide,0.5％ BSA and 50％ glycerol pH 7.4.
Dilution：WB 1：500-1：2000, IHC 1：100-1：300, IF 1：200-1：1000, ELISA 1：5000
