Background：Involved in intracellular signal transduction mediated by cytokines and growth factors. Upon IL-2 and GM-CSL stimulation, it plays a role in signaling leading to DNA synthesis and MYC induction. May also play a role in T-cell development. Involved in down-regulation of receptor tyrosine kinase via multivesicular body （MVBs） when complexed with HGS （ESCRT-0 complex）. The ESCRT-0 complex binds ubiquitin and acts as sorting machinery that recognizes ubiquitinated receptors and transfers them to further sequential lysosomal sorting/trafficking processes.
仕様
Synonyms：DKFZp564C047,Hbp,Hrs-binding protein,HSE1 homolog,Signal transducing adapter molecule 2,Signal transducing adaptor molecule （SH3 domain and ITAM motif） 2,Signal transducing adaptor molecule 2A,Signal transducing adaptor molecule 2B,Signal transducing adaptor molecule,STAM like protein containing SH3 and ITAM domains 2,STAM-2,Stam2,STAM2,STAM2A,STAM2B
Host：Rabbit
Reactivity：Human,Mouse
Applications：WB,IHC-p,ELISA
Concentration：1mg/mL
Immunogen：Synthesized peptide derived from human STAM2 around the phosphorylation site of Y192.
Purification Method：Affinity purification
Clonality：Polyclonal
Conjugation：Unconjugated
Buffer：PBS with 0.02％ sodium azide,0.5％ BSA and 50％ glycerol pH 7.4.
