Background：Binds the telomeric double-stranded TTAGGG repeat and negatively regulates telomere length. Involved in the regulation of the mitotic spindle. Component of the shelterin complex （telosome） that is involved in the regulation of telomere length and protection. Shelterin associates with arrays of double-stranded TTAGGG repeats added by telomerase and protects chromosome ends; without its protective activity, telomeres are no longer hidden from the DNA damage surveillance and chromosome ends are inappropriately processed by DNA repair pathways.
仕様
Synonyms：hTRF1 AS,NIMA interacting protein 2,NIMA-interacting protein 2,PIN 2,PIN2,t TRF1,Telomeric protein Pin2,Telomeric protein Pin2/TRF1,Telomeric repeat binding factor （NIMA interacting） 1,Telomeric repeat binding factor 1,Telomeric repeat binding protein 1,Telomeric repeat-binding factor 1,TERF 1,Terf1,TERF1,TRBF 1,TRBF1,TRF 1,TRF,TTAGGG repeat binding factor 1,TTAGGG repeat-binding factor 1
Host：Rabbit
Reactivity：Human,Mouse
Applications：WB,ELISA
Concentration：1mg/mL
Immunogen：Synthesized peptide derived from human TRF1 around the phosphorylation site of S219.
Purification Method：Affinity purification
Clonality：Polyclonal
Conjugation：Unconjugated
Buffer：PBS with 0.02％ sodium azide,0.5％ BSA and 50％ glycerol pH 7.4.
Dilution：WB 1：500-1：2000, ELISA 1：5000
Gene_ID（human）：7013
Swissprot：P54274
Isotype：IgG
Research Areas：Cancer, Epigenetics and Nuclear Signaling, Tags ＆ Cell Markers
