Background：The human glucocorticoid receptor DNA binding factor, which associates with the promoter region of the glucocorticoid receptor gene （hGR gene）, is a repressor of glucocorticoid receptor transcription. The amino acid sequence deduced from the cDNA sequences show the presence of three sequence motifs characteristic of a zinc finger and one motif suggestive of a leucine zipper in which 1 cysteine is found instead of all leucines. The GRLF1 enhances the homologous down-regulation of wild-type hGR gene expression. Biochemical analysis suggests that GRLF1 interaction is sequence specific and that transcriptional efficacy of GRLF1 is regulated through its interaction with specific sequence motif. The level of expression is regulated by glucocorticoids.
仕様
Synonyms：ARHGAP35,GAP associated protein p190,Glucocorticoid receptor DNA binding factor 1,Glucocorticoid receptor DNA-binding factor 1,Glucocorticoid receptor repression factor 1,GRF 1,GRF-1,GRF1,GRLF 1,GRLF1,GRLF1,KIAA1722,MGC10745,p190 A,p190-A,P190A,P190A,rat,homolog of,p190ARhoGAP,p190RhoGAP,Rho GAP p190A,Rho GTPase-activating protein 35
Host：Rabbit
Reactivity：Human,Mouse,Rat
Applications：WB,ELISA
Concentration：1mg/mL
Immunogen：Synthesized peptide derived from human GRF-1 around the phosphorylation site of Y1087.
Purification Method：Affinity purification
Clonality：Polyclonal
Conjugation：Unconjugated
Buffer：PBS with 0.02％ sodium azide,0.5％ BSA and 50％ glycerol pH 7.4.
