Background：Receptor tyrosine kinases （RTKs） are transmembrane molecular scaffolds that influence cellular processes including the cell cycle, cell migration, cell metabolism, cell survival, proliferation and differentiation. Insulin-like rowth factor-I receptor （IGF-IR） is an RTK that stimulates growth in many different cell types, blocks apoptosis, acts as an intermediate of many growth hormone responses and may stimulate the growth of some types of cancer. The IGF-IR cognate ligand Insulin-like growth factor-I （IGF-I） promotes association of IGF-IR with Shc, GRB2 and Sos 1, which initiates Ras and ERK kinase cascades,thereby modifying transcription factor activity, such as activation of the Elk transcription factors. The modular phosphotyrosine-binding （PTB） domains of Insulin receptor substrates （IRS）-1 and -2 can associate with active IGF-IR and initiate phosphatidylinositol 3-kinase-dependent downstream signals. The human IGF-IR gene maps to chromosome 15q26.3 and encodes a 1,376 amino acid precursor protein that cleaves into a and b subunits. The human IGF-IIR gene maps to chromosome 6q26 and encodes a 2,491 amino acid ransmembrane protein.
仕様
Synonyms：CD221,CD221 antigen,IGF 1 receptor,IGF 1R,IGF I receptor,IGF-I receptor,Igf1r,IGF1R,IGFIR,IGFIRC,IGFR,Insulin like growth factor 1 receptor,Insulin like growth factor 1 receptor precursor,Insulin-like growth factor 1 receptor beta chain,Insulin-like growth factor I receptor,JTK13,MGC142170,MGC142172,MGC18216,Soluble IGF1R variant 1,Soluble IGF1R variant 2
Host：Rabbit
Reactivity：Human,Mouse,Rat,Monkey
Applications：WB,ELISA
Concentration：1mg/mL
Immunogen：Synthesized peptide derived from human IGF-IR around the phosphorylation site of Y1165/Y1166.
Purification Method：Affinity purification
Clonality：Polyclonal
Conjugation：Unconjugated
Buffer：PBS with 0.02％ sodium azide,0.5％ BSA and 50％ glycerol pH 7.4.
Dilution：WB 1：500-1：2000, ELISA 1：20000
Gene_ID（human）：3480
Swissprot：P08069
Isotype：IgG
Research Areas：Cancer, Developmental biology, Signal transduction
