Background：Receptor-regulated SMAD （R-SMAD） that is an intracellular signal transducer and transcriptional modulator activated by TGF-beta （transforming growth factor） and activin type 1 receptor kinases. Binds the TRE element in the promoter region of many genes that are regulated by TGF-beta and, on formation of the SMAD3/SMAD4 complex, activates transcription. Also can form a SMAD3/SMAD4/JUN/FOS complex at the AP-1/SMAD site to regulate TGF-beta-mediated transcription. Has an inhibitory effect on wound healing probably by modulating both growth and migration of primary keratinocytes and by altering the TGF-mediated chemotaxis of monocytes. This effect on wound healing appears to be hormone-sensitive. Regulator of chondrogenesis and osteogenesis and inhibits early healing of bone fractures. Positively regulates PDPK1 kinase activity by stimulating its dissociation from the 14-3-3 protein YWHAQ which acts as a negative regulator.
仕様
Synonyms：DKFZP586N0721,DKFZp686J10186,hMAD 3,hMAD-3,hSMAD3,HSPC193,HST17436,JV15 2,JV15-2,JV152,LDS1C,LDS3,MAD （mothers against decapentaplegic Drosophila） homolog 3,MAD homolog 3,Mad homolog JV15 2,Mad protein homolog,MAD,mothers against decapentaplegic homolog 3,Mad3,MADH 3,MADH3,MGC60396,Mothers against decapentaplegic homolog 3,Mothers against DPP homolog 3,SMA and MAD related protein 3,SMAD 3,SMAD,SMAD family member 3,SMAD,mothers against DPP homolog 3,Smad3,SMAD3
Host：Mouse
Reactivity：Human,Mouse,Rat
Applications：IHC-p
Concentration：1mg/mL
Immunogen：Synthetic Peptide of Phospho-Smad3 （Ser425）
Purification Method：Protein A purification
Clonality：Monoclonal
Clone No.：4C5
Conjugation：Unconjugated
Buffer：PBS with 0.02％ sodium azide, 50％ glycerol, pH7.4
Dilution：IHC 1：50-300
Gene_ID（human）：4088
Swissprot：P84022
Isotype：IgG
Research Areas：Cancer, Epigenetics and Nuclear Signaling, Metabolism, Signal transduction, Stem cells
