Background：The protein encoded by this gene is a cytoplasmic kinase that is structurally similar to the yeast Ste20p kinase, which acts upstream of the stress-induced mitogen-activated protein kinase cascade. The encoded protein can phosphorylate myelin basic protein and undergoes autophosphorylation. A caspase-cleaved fragment of the encoded protein has been shown to be capable of phosphorylating histone H2B. The particular phosphorylation catalyzed by this protein has been correlated with apoptosis, and it's possible that this protein induces the chromatin condensation observed in this process.
仕様
Synonyms：Antigen NY-CO-13,BCC7,Cellular tumor antigen p53,FLJ92943,LFS1,Mutant tumor protein 53,p53,p53 tumor suppressor,P53,Phosphoprotein p53,Tp53,Transformation related protein 53,TRP53,Tumor protein 53,Tumor protein p53,Tumor suppressor p53
Host：Mouse
Reactivity：Human,Mouse,Rat
Applications：IHC-p
Concentration：1mg/mL
Immunogen：Synthetic Peptide
Purification Method：Protein A purification
Clonality：Monoclonal
Clone No.：4A1
Conjugation：Unconjugated
Buffer：PBS with 0.02％ sodium azide, 50％ glycerol, pH7.4
Dilution：IHC 1：50-1：200
Gene_ID（human）：7157
Swissprot：P04637
Isotype：IgG
Research Areas：Cancer, Cell Biology, Epigenetics and Nuclear Signaling
