Background：The protein encoded by this gene, a member of the Wiskott-Aldrich syndrome protein （WASP）-family, plays a critical role downstream of Rac, a Rho-family small GTPase, in regulating the actin cytoskeleton required for membrane ruffling. It has been shown to associate with an actin nucleation core Arp2/3 complex while enhancing actin polymerization in vitro. Wiskott-Aldrich syndrome is a disease of the immune system, likely due to defects in regulation of actin cytoskeleton. Multiple alternatively spliced transcript variants encoding the same protein have been found for this gene.WASF1 （WAS Protein Family Member 1） is a Protein Coding gene. Diseases associated with WASF1 include Wiskott-Aldrich Syndrome and Spinocerebellar Ataxia With Axonal Neuropathy Type 2. Among its related pathways are Innate Immune System and RET signaling. GO annotations related to this gene include actin binding and Rac GTPase binding. An important paralog of this gene is WASF2.
仕様
Synonyms：WASP family,verprolin homology domain-containing protein 1,WASP family member 1,FLJ31482,homology of dictyostelium scar 1,KIAA0269,Protein WAVE-1,Protein WAVE1,scar,Dictyostelium,homology of,1,SCAR1,Similar to a plant extensin like protein,Verprolin homology domain containing protein 1,Verprolin homology domain-containing protein 1,WAS protein family,member 1,Wasf1,WASF1,WASL,WASP family 1,WASP family protein member 1,WASP family,verprolin homology domain-containing protein,WAVE,WAVE1,Wiskott Aldrich syndrome protein family member 1,Wiskott-Aldrich syndrome protein family member 1
Host：Rabbit
Reactivity：Human,Mouse,Rat
Applications：WB,IHC-p,IF,ELISA
Concentration：1mg/mL
Immunogen：Synthesized peptide derived from human WAVE1 around the phosphorylation site of Tyr125
Purification Method：Affinity purification
Clonality：Polyclonal
Conjugation：Unconjugated
Buffer：PBS with 0.02％ sodium azide, 0.5％ BSA and 50％ glycerol, pH7.4
Dilution：WB 1：500-1：2000, IHC 1：100-1：300, IF 1：200-1：1000, ELISA 1：5000
Gene_ID（human）：8936
Swissprot：Q92558
Isotype：IgG
Research Areas：Cancer, Metabolism, Neuroscience, Signal transduction
