Background：Core binding factor （CBF） is a heterodimeric transcription factor that binds to the core element of many enhancers and promoters. The protein encoded by this gene represents the alpha subunit of CBF and is thought to be involved in the development of normal hematopoiesis. Chromosomal translocations involving this gene are well-documented and have been associated with several types of leukemia. Three transcript variants encoding different isoforms have been found for this gene
仕様
Synonyms：Acute myeloid leukemia 1,Acute myeloid leukemia 1 protein,alpha subunit core binding factor,AML 1,AML1,AML1 EVI 1,AML1 EVI 1 fusion protein,Aml1 oncogene,AMLCR 1,AMLCR1,CBF alpha 2,CBF-alpha-2,CBFA 2,CBFA2,Core binding factor alpha 2 subunit,Core binding factor runt domain alpha subunit 2,Core-binding factor subunit alpha-2,EVI 1,EVI1,HGNC,Oncogene AML 1,Oncogene AML-1,OTTHUMP00000108696,OTTHUMP00000108697,OTTHUMP00000108699,OTTHUMP00000108700,OTTHUMP00000108702,PEA2 alpha B,PEA2-alpha B,PEBP2 alpha B,PEBP2-alpha B,PEBP2A2,PEBP2aB,Polyomavirus enhancer binding protein 2 alpha B subunit,Polyomavirus enhancer-binding protein 2 alpha B subunit,Run1,Runt related transcription factor 1,Runt-related transcription factor 1,RUNX 1,Runx1,RUNX1,SL3 3 enhancer factor 1 alpha B subunit,SL3-3 enhancer factor 1 alpha B subunit,SL3/AKV core binding factor alpha B subunit,SL3/AKV core-binding factor alpha B subunit
Host：Rabbit
Reactivity：Human,Mouse,Rat
Applications：WB,ELISA
Concentration：1mg/mL
Immunogen：Synthesized peptide derived from human RUNX1 around the phosphorylation site of Ser249
Purification Method：Affinity purification
Clonality：Polyclonal
Conjugation：Unconjugated
Buffer：PBS with 0.02％ sodium azide, 0.5％ BSA and 50％ glycerol, pH7.4
Dilution：WB 1：500-1：2000, ELISA 1：5000
Gene_ID（human）：861
Swissprot：Q01196
Isotype：IgG
Research Areas：Cancer, Epigenetics and Nuclear Signaling, Developmental biology, Neuroscience, Stem cells
