Background：CaM-kinase II （CAMK2） is a prominent kinase in the central nervous system that may function in long-term potentiation and neurotransmitter release. Member of the NMDAR signaling complex in excitatory synapses it may regulate NMDAR-dependent potentiation of the AMPAR and synaptic plasticity （By similarity）. Phosphorylates transcription factor FOXO3 on Ser-298 （PubMed：23805378）. Activates FOXO3 transcriptional activity （By similarity）.
仕様
Synonyms：CAMK2A,CAMKA,KIAA0968,Calcium/calmodulin-dependent protein kinase type II subunit alpha,CaM kinase II subunit alpha,CaMK-II subunit alpha,CAMK2D,CAMKD,Calcium/calmodulin-dependent protein kinase type II subunit delta,CaM kinase II
Host：Rabbit
Reactivity：Human,Mouse,Rat
Applications：WB,IHC-p,IF,ELISA
Concentration：1mg/mL
Immunogen：Synthesized peptide derived from human CaMKIIa/delta around the phosphorylation site of Thr286
Purification Method：Affinity purification
Clonality：Polyclonal
Conjugation：Unconjugated
Buffer：PBS with 0.02％ sodium azide, 0.5％ BSA and 50％ glycerol, pH7.4
Dilution：WB 1：500-1：2000, IHC 1：100-1：300, IF 1：200-1：1000, ELISA 1：10000
Gene_ID（human）：815/817
Swissprot：Q9UQM7,Q13557
Isotype：IgG
Research Areas：Cancer, Cardiovascular, Metabolism, Neuroscience, Signal transduction
