Background：The protein encoded by this gene is the founding member of the protein tyrosine phosphatase （PTP） family, which was isolated and identified based on its enzymatic activity and amino acid sequence. PTPs catalyze the hydrolysis of the phosphate monoesters specifically on tyrosine residues. Members of the PTP family share a highly conserved catalytic motif, which is essential for the catalytic activity. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP has been shown to act as a negative regulator of insulin signaling by dephosphorylating the phosphotryosine residues of insulin receptor kinase. This PTP was also reported to dephosphorylate epidermal growth factor receptor kinase, as well as JAK2 and TYK2 kinases, which implicated the role of this PTP in cell growth control, and cell response to interferon stimulation. Two transcript variants encoding different isoforms have been found for this gene.
仕様
Synonyms：PTP1B,Non receptor tyrosine phosphatase 1,Protein phosphotyrosylphosphatase 1B,Protein tyrosine phosphatase 1B,Protein tyrosine phosphatase non receptor type 1,Protein tyrosine phosphatase placental,Protein-tyrosine phosphatase 1B,PTN1,PTP 1B,PTP-1B,PTPN 1,PTPN1,Tyrosine protein phosphatase non receptor type 1,Tyrosine-protein phosphatase non-receptor type 1
Host：Rabbit
Reactivity：Human,Mouse,Rat,Monkey
Applications：WB,IHC-p,ELISA
Concentration：1mg/mL
Immunogen：Synthesized peptide derived from human PTP1B around the phosphorylation site of Ser50
Purification Method：Affinity purification
Clonality：Polyclonal
Conjugation：Unconjugated
Buffer：PBS with 0.02％ sodium azide, 0.5％ BSA and 50％ glycerol, pH7.4
