Background：The protein encoded by this gene is a member of the Tyro3-Axl-Mer （TAM） receptor tyrosine kinase subfamily. The encoded protein possesses an extracellular domain which is composed of two immunoglobulin-like motifs at the N-terminal, followed by two fibronectin type-III motifs. It transduces signals from the extracellular matrix into the cytoplasm by binding to the vitamin K-dependent protein growth arrest-specific 6 （Gas6）. This gene may be involved in several cellular functions including growth, migration, aggregation and anti-inflammation in multiple cell types. Alternative splicing results in multiple transcript variants of this gene.AXL （AXL Receptor Tyrosine Kinase） is a Protein Coding gene. Diseases associated with AXL include Lymphocytic Choriomeningitis and Femoral Neuropathy. Among its related pathways are GPCR Pathway and RET signaling. GO annotations related to this gene include transferase activity, transferring phosphorus-containing groups and protein tyrosine kinase activity. An important paralog of this gene is MERTK.
仕様
Synonyms：Adhesion related kinase,AI323647,Ark,Axl,AXL oncogene,AXL receptor tyrosine kinase,AXL transforming gene,AXL transforming sequence/gene,EC 2.7.10.1,JTK11,Oncogene AXL,Tyro7,Tyrosine protein kinase receptor UFO,Tyrosine-protein kinase receptor UFO,UFO,UFO
Host：Rabbit
Reactivity：Human,Mouse,Rat
Applications：WB,IHC-p,ELISA
Concentration：1mg/mL
Immunogen：Synthesized peptide derived from human Axl around the phosphorylation site of Tyr691
Purification Method：Affinity purification
Clonality：Polyclonal
Conjugation：Unconjugated
Buffer：PBS with 0.02％ sodium azide, 0.5％ BSA and 50％ glycerol, pH7.4
