Background：This gene encodes a member of the cytosolic phospholipase A2 group IV family. The enzyme catalyzes the hydrolysis of membrane phospholipids to release arachidonic acid which is subsequently metabolized into eicosanoids. Eicosanoids, including prostaglandins and leukotrienes, are lipid-based cellular hormones that regulate hemodynamics, inflammatory responses, and other intracellular pathways. The hydrolysis reaction also produces lysophospholipids that are converted into platelet-activating factor. The enzyme is activated by increased intracellular Ca（2+） levels and phosphorylation, resulting in its translocation from the cytosol and nucleus to perinuclear membrane vesicles.
仕様
Synonyms：PLA2G4A,CPLA2,PLA2G4,Cytosolic phospholipase A2,cPLA2,Phospholipase A2 group IVA
Host：Rabbit
Reactivity：Human,Mouse,Rat
Applications：WB,IHC-p,IF,ELISA
Concentration：1mg/mL
Immunogen：Synthesized peptide derived from human cPLA2 around the phosphorylation site of Ser505
Purification Method：Affinity purification
Clonality：Polyclonal
Conjugation：Unconjugated
Buffer：PBS with 0.02％ sodium azide, 0.5％ BSA and 50％ glycerol, pH7.4
Dilution：WB 1：500-1：2000, IHC 1：100-1：300, IF 1：200-1：1000, ELISA 1：10000
Gene_ID（human）：5321
Swissprot：P47712
Isotype：IgG
Research Areas：Cancer, Cardiovascular, Metabolism, Immunology, Signal transduction
