Background：Functions within a multiprotein E3 ubiquitin ligase complex, catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins, such as BCL2, SYT11, CCNE1, GPR37, STUB1, a 22 kDa O-linked glycosylated isoform of SNCAIP, SEPT5, ZNF746 and AIMP2. Mediates monoubiquitination as well as 'Lys-48'-linked and 'Lys-63'-linked polyubiquitination of substrates depending on the context. Participates in the removal and/or detoxification of abnormally folded or damaged protein by mediating 'Lys-63'-linked polyubiquitination of misfolded proteins such as PARK7： 'Lys-63'-linked polyubiquitinated misfolded proteins are then recognized by HDAC6, leading to their recruitment to aggresomes, followed by degradation. Mediates 'Lys-63'-linked polyubiquitination of SNCAIP, possibly playing a role in Lewy-body formation. Mediates monoubiquitination of BCL2, thereby acting as a positive regulator of autophagy. Promotes the autophagic degradation of dysfunctional depolarized mitochondria. Mediates 'Lys-48'-linked polyubiquitination of ZNF746, followed by degradation of ZNF746 by the proteasome; possibly playing a role in role in regulation of neuron death. Limits the production of reactive oxygen species （ROS）. Loss of this ubiquitin ligase activity appears to be the mechanism underlying pathogenesis of PARK2.
仕様
Synonyms：AR JP,E3 ubiquitin ligase,E3 ubiquitin protein ligase parkin,E3 ubiquitin-protein ligase parkin,FRA6E,LPRS 2,LPRS2,PARK 2,Park2,Parkin 2,Parkinson disease （autosomal recessive juvenile） 2,Parkinson disease （autosomal recessive,juvenile） 2,parkin,Parkinson disease protein 2,Parkinson juvenile disease protein 2,Parkinson protein 2 E3 ubiquitin protein ligase,Parkinson protein 2,E3 ubiquitin protein ligase （parkin）,PDJ,PRKN 2,PRKN,PRKN2,PRKN2,Ubiquitin E3 ligase PRKN
Host：Rabbit
Reactivity：Human
Applications：WB,IHC-p,ELISA
Concentration：1mg/mL
Immunogen：Synthesized peptide derived from human Parkin around the phosphorylation site of Ser131
Purification Method：Affinity purification
Clonality：Polyclonal
Conjugation：Unconjugated
Buffer：PBS with 0.02％ sodium azide, 0.5％ BSA and 50％ glycerol, pH7.4
