Background：This gene encodes a member of the neurotrophic tyrosine receptor kinase （NTRK） family. This kinase is a membrane-bound receptor that, upon neurotrophin binding, phosphorylates itself and members of the MAPK pathway. signaling through this kinase leads to cell differentiation and may play a role in the development of proprioceptive neurons that sense body position. Mutations in this gene have been associated with medulloblastomas, secretory breast carcinomas and other cancers. Several transcript variants encoding different isoforms have been found for this gene.
仕様
Synonyms：EC 2.7.10.1,ETS related protein neurotrophic receptor tyrosine kinase fusion,ETS related protein neurotrophic receptor tyrosine kinase fusion protein,ETV6 NTRK3 fusion,GP145 TrkC,gp145（trkC）,GP145-TrkC,GP145TrkC,Neurotrophic tyrosine kinase receptor type 3,Neurotrophin 3 receptor,NT 3 growth factor receptor,NT 3 growth factor receptor precursor,NT 3 receptor,NT-3 growth factor receptor,Ntrk3,NTRK3,OTTHUMP00000192915,TRK C,Trk-C,TRKC,TrkC tyrosine kinase,Tyrosine kinase receptor C
Host：Rabbit
Reactivity：Human,Mouse,Rat
Applications：WB,IHC-p,ELISA
Concentration：1mg/mL
Immunogen：Synthesized peptide derived from human Trk C around the phosphorylation site of Tyr516
Purification Method：Affinity purification
Clonality：Polyclonal
Conjugation：Unconjugated
Buffer：PBS with 0.02％ sodium azide, 0.5％ BSA and 50％ glycerol, pH7.4
