Background：The protein encoded by this gene is a serine/threonine kinase and is part of some signal transduction cascades, including the ERK and JNK kinase pathways as well as the NF-kappa-B pathway. The encoded protein is activated by autophosphorylation and requires magnesium as a cofactor in phosphorylating other proteins. This protein has E3 ligase activity conferred by a plant homeodomain （PHD） in its N-terminus and phospho-kinase activity conferred by a kinase domain in its C-terminus.MAP3K1 （Mitogen-Activated Protein Kinase Kinase Kinase 1） is a Protein Coding gene. Diseases associated with MAP3K1 include 46Xy Sex Reversal 6 and 46 Xy Gonadal Dysgenesis. Among its related pathways are Development VEGF signaling via VEGFR2 - generic cascades and Development Endothelin-1/EDNRA signaling. GO annotations related to this gene include transferase activity, transferring phosphorus-containing groups and protein tyrosine kinase activity. An important paralog of this gene is MAP3K19.
仕様
Synonyms：M3K1,MAP3K1,MAPK/ERK kinase kinase 1,MAPKKK1,MEK kinase 1,MEKK 1,Mekk,MEKK1,Mitogen activated protein kinase kinase kinase 1,Mitogen activated protein kinase kinase kinase 1,E3 ubiquitin protein ligase,Mitogen-activated protein kinase kinase kinase 1,SRXY6
Host：Rabbit
Reactivity：Human,Mouse,Rat
Applications：WB,IHC-p,ELISA
Concentration：1mg/mL
Immunogen：Synthesized peptide derived from human MEK Kinase-1 around the phosphorylation site of Thr1400
Purification Method：Affinity purification
Clonality：Polyclonal
Conjugation：Unconjugated
Buffer：PBS with 0.02％ sodium azide, 0.5％ BSA and 50％ glycerol, pH7.4
