Background：Integrins are heterodimers comprised of alpha and beta subunits, that are noncovalently associated transmembrane glycoprotein receptors. Different combinations of alpha and beta polypeptides form complexes that vary in their ligand-binding specificities. Integrins mediate cell-matrix or cell-cell adhesion, and transduced signals that regulate gene expression and cell growth. This gene encodes the integrin beta 4 subunit, a receptor for the laminins. This subunit tends to associate with alpha 6 subunit and is likely to play a pivotal role in the biology of invasive carcinoma. Mutations in this gene are associated with epidermolysis bullosa with pyloric atresia. Multiple alternatively spliced transcript variants encoding distinct isoforms have been found for this gene.ITGB4 （Integrin Subunit Beta 4） is a Protein Coding gene. Diseases associated with ITGB4 include Epidermolysis Bullosa, Junctional, With Pyloric Stenosis and Epidermolysis Bullosa, Junctional, Non-Herlitz Type. Among its related pathways are GPCR Pathway and MAPK-Erk Pathway. GO annotations related to this gene include receptor activity and G-protein coupled receptor binding. An important paralog of this gene is ITGB1.
