Background：This gene encodes a member of the family of voltage-gated potassium （Kv） channel-interacting proteins, which belong to the recoverin branch of the EF-hand superfamily. Members of this family are small calcium binding proteins containing EF-hand-like domains. They are integral subunit components of native Kv4 channel complexes that may regulate A-type currents, and hence neuronal excitability, in response to changes in intracellular calcium. The encoded protein also functions as a calcium-regulated transcriptional repressor, and interacts with presenilins. Alternatively spliced transcript variants encoding different isoforms have been described. KCNIP3 （Potassium Voltage-Gated Channel Interacting Protein 3） is a Protein Coding gene. Diseases associated with KCNIP3 include Alzheimer Disease. Among its related pathways are Cardiac conduction and Development Ligand-independent activation of ESR1 and ESR2. GO annotations related to this gene include calcium ion binding and transcription corepressor activity. An important paralog of this gene is KCNIP4.
仕様
Synonyms：4933407H12Rik,A type potassium channel modulatory protein 3,A-type potassium channel modulatory protein 3,AI413860,Calsenilin,CSEN,CSEN,DRE antagonist modulator,DRE-antagonist modulator,DREAM,EF hand transcription factor,KCHIP 3,KChIP3,KCNIP 3,Kcnip3,Kv channel interacting protein 3,Kv channel-interacting protein 3,MGC18289,Potassium channel interacting protein 3,R74849
Host：Rabbit
Reactivity：Human,Mouse
Applications：WB,IHC-p,IF,ELISA
Concentration：1mg/mL
Immunogen：Synthesized peptide derived from human DREAM around the phosphorylation site of Ser63
Purification Method：Affinity purification
Clonality：Polyclonal
Conjugation：Unconjugated
Buffer：PBS with 0.02％ sodium azide, 0.5％ BSA and 50％ glycerol, pH7.4
Dilution：WB 1：500-1：2000, IHC 1：100-1：300, IF 1：200-1：1000, ELISA 1：20000
Gene_ID（human）：30818
Swissprot：Q9Y2W7
Isotype：IgG
Research Areas：Cancer, Cardiovascular, Neuroscience, Signal transduction
