Background：The protein encoded by this gene is a member of the fibroblast growth factor receptor family, where amino acid sequence is highly conserved between members and throughout evolution. FGFR family members differ from one another in their ligand affinities and tissue distribution. A full-length representative protein would consist of an extracellular region, composed of three immunoglobulin-like domains, a single hydrophobic membrane-spanning segment and a cytoplasmic tyrosine kinase domain. The extracellular portion of the protein interacts with fibroblast growth factors, setting in motion a cascade of downstream signals, ultimately influencing mitogenesis and differentiation. FGFR4 （Fibroblast Growth Factor Receptor 4） is a Protein Coding gene. Diseases associated with FGFR4 include Prostate Cancer and Neuroma. Among its related pathways are GPCR Pathway and RET signaling. GO annotations related to this gene include transferase activity, transferring phosphorus-containing groups and protein tyrosine kinase activity. An important paralog of this gene is FGFR3.
仕様
Synonyms：CD 334,CD334,CD334 antigen,fc13h 10,fc13h10,Fgfr 4,FGFR-4,Fgfr4,FGFR4,Fibroblast growth factor receptor 4,Hydroxyaryl protein kinase,JTK 2,JTK2,MGC20292,Protein tyrosine kinase,TKF,Tyrosine kinase related to fibroblast growth factor receptor,Tyrosylprotein kinase
Host：Rabbit
Reactivity：Human,Mouse,Rat
Applications：WB,ELISA
Concentration：1mg/mL
Immunogen：Synthesized peptide derived from human FGFR-4 around the phosphorylation site of Tyr642
Purification Method：Affinity purification
Clonality：Polyclonal
Conjugation：Unconjugated
Buffer：PBS with 0.02％ sodium azide, 0.5％ BSA and 50％ glycerol, pH7.4
Dilution：WB 1：500-1：2000, ELISA 1：10000
Gene_ID（human）：2264
Swissprot：P22455
Isotype：IgG
Research Areas：Cancer, Cell Biology, Cardiovascular, Neuroscience, Signal transduction, Stem cells, Tags ＆ Cell Markers
