Background：Ephrin B proteins are thought to play key roles in cellular functions as diverse as neuronal migration and blood vessel development. Ephrin B molecules expressed at the membrane surface bind to the Ephrin B family receptors on target cells during cell to cell contact. This interaction leads to cell signaling in the target cell but also generates a reverse signal in the cell expressing Ephrin B on its surface. This reverse signaling event is thought to be critical for vessel maturation and neuronal development. Importantly, tyrosine phosphorylation of Ephrin B is thought to be a critical component of this reverse signaling event. Recent work demonstrated that Tyr331 of Ephrin B was phosphorylated in HEK293 cells after stimulation by the soluble Ephrin B2 receptor tyrosine kinase.
仕様
Synonyms：CFND,CFNS,Craniofrontonasal syndrome （craniofrontonasal dysplasia）,EFL 3,EFL-3,EFL3,EFNB1,EFNB1,Elk L,ELK ligand,ELK-L,Eph related receptor tyrosine kinase ligand 2,EPH-related receptor tyrosine kinase ligand 2,Ephrin-B1,EPLG2,LERK 2,LERK-2,LERK2,Ligand of eph related kinase 2,MGC8782
Host：Rabbit
Reactivity：Human,Mouse,Rat
Applications：WB,ELISA
Concentration：1mg/mL
Immunogen：Synthesized peptide derived from human Ephrin-B1 around the phosphorylation site of Tyr317
Purification Method：Affinity purification
Clonality：Polyclonal
Conjugation：Unconjugated
Buffer：PBS with 0.02％ sodium azide, 0.5％ BSA and 50％ glycerol, pH7.4
Dilution：WB 1：500-1：2000, ELISA 1：20000
Gene_ID（human）：1947
Swissprot：P98172
Isotype：IgG
Research Areas：Cell Biology, Cardiovascular, Developmental biology, Neuroscience, Signal transduction
