Background：Serine/threonine kinase which acts as a positive regulator of apoptosis. Phosphorylates histone H3 on 'Thr-11' at centromeres during mitosis. Regulates myosin light chain phosphatase through phosphorylation of MYPT1 thereby regulating the assembly of the actin cytoskeleton, cell migration, invasiveness of tumor cells, smooth muscle contraction and neurite outgrowth. Involved in the formation of promyelocytic leukemia protein nuclear body （PML-NB）, one of many subnuclear domains in the eukaryotic cell nucleus, and which is involved in oncogenesis and viral infection.
仕様
Synonyms：DAP kinase 3,DAP like kinase,DAP-like kinase,Dapk 3,DAPK3,DAPK3,Death associated kinase 3,Death associated protein kinase 3,Death-associated protein kinase 3,Dlk,EC 2.7.11.1,FLJ36473,MYPT1 kinase,ZIP,ZIP kinase,ZIP kinase isoform,ZIP-kinase,ZIPK,zipper-interacting protein kinase
Host：Rabbit
Reactivity：Human,Mouse,Rat
Applications：WB,IHC-p,IF,ELISA
Concentration：1mg/mL
Immunogen：Synthesized peptide derived from human DAPK3 around the phosphorylation site of Thr265
Purification Method：Affinity purification
Clonality：Polyclonal
Conjugation：Unconjugated
Buffer：PBS with 0.02％ sodium azide, 0.5％ BSA and 50％ glycerol, pH7.4
Dilution：WB 1：500-1：2000, IHC 1：100-1：300, IF 1：200-1：1000, ELISA 1：10000
Gene_ID（human）：1613
Swissprot：O43293
Isotype：IgG
Research Areas：Cancer, Cell Biology, Signal transduction
